Allulose and GLP-1 (Ozempic)

Allulose and GLP-1 (Ozempic)

Unveiling the Sweet Secret: Allulose - A Game Changer in the World of Sweeteners

Unlocking the Potential of Allulose and GLP-1 for Weight Management

In the ever-evolving landscape of health and wellness, the quest for effective weight management solutions remains a top priority for many. Recently, the spotlight has shifted towards a new class of medications known as GLP-1 drugs, with names like Ozempic and Wegovy making waves in the health community, particularly in the United States. These medications, hailed for their ability to promote weight loss and stabilize blood sugar levels, have garnered widespread attention and acclaim.

But amidst the buzz surrounding GLP-1 drugs, another player has emerged: allulose. This low-calorie, low-carb sweetener has been making waves in the health food industry for its potential to mimic the effects of GLP-1, offering a promising avenue for weight management and metabolic health.

What is GLP-1

GLP-1, or Glucagon-Like Peptide-1, is a hormone released from the gut after consuming meals. It signals the body to release insulin, aiding in blood sugar reduction.

Produced in the intestines, GLP-1 supports stable blood sugar levels, slows digestion, promotes satiety (feeling of fullness), and prevents excess glucose production by the liver. All these things can ultimately promote weight loss.

When we consider the vital role of GLP-1 in blood sugar regulation and digestion, we can see there are several benefits:

  • Glucose Management in Type 2 Diabetes
  • Appetite Management and Weight Loss Facilitation
  • Reduced Risk of Heart Disease
  • Energy Maintenance
  • Prevention of Diabetes
  • Support for Metabolic Health


Understanding GLP-1: The Key to Weight Management

At the heart of this discussion lies GLP-1, or Glucagon-Like Peptide-1, a hormone naturally released by the gut in response to food intake. GLP-1 plays a crucial role in regulating blood sugar levels, promoting satiety, slowing digestion, and even preventing excess glucose production by the liver. These functions make it a key player in appetite management, weight loss facilitation, and overall metabolic health.

Allulose: A Sweet Solution

Enter allulose, a rare sugar found naturally in certain fruits like figs. With 90% fewer calories than sugar and minimal metabolism in the body, allulose has garnered attention as a promising alternative sweetener. But recent studies have unveiled another dimension to its potential: the ability to trigger the release of GLP-1, similar to the effects of GLP-1 drugs like Ozempic.

The Evidence: Allulose and GLP-1

A growing body of research supports the link between allulose consumption and GLP-1 release. Studies have shown that allulose can attenuate postprandial blood glucose levels, reduce insulin requirements, and even suppress hunger-associated feeding by inhibiting hunger-promoting neurons in the hypothalamic arcuate nucleus (ARC). These findings suggest that allulose may offer multiple benefits for weight management and metabolic health.

Real-world Implications

The potential of allulose as a weight management tool extends beyond the laboratory. Products like Two Spoons ice cream, which use allulose as their main sweetener, offer consumers a delicious yet guilt-free treat with added metabolic benefits. Furthermore, incorporating allulose into diabetic diets has shown promise in improving postprandial blood glucose levels and reducing insulin requirements in patients with type 2 diabetes.


Looking Ahead

While the evidence supporting the role of allulose in GLP-1 release and weight management is promising, further research is needed to fully understand its mechanisms of action and long-term effects. Continued investigation into the potential benefits of allulose, both as a sweetener and a metabolic regulator, holds promise for the future of weight management and metabolic health.


Read more about GLP-1 Studies:

Tani, Y., Tokuda, M., Nishimoto, N., Yokoi, H., & Izumori, K. (2023, April 6). Allulose for the attenuation of postprandial blood glucose levels in healthy humans: A systematic review and meta-analysis. PLoS One.

Fukunaga, K., Yoshimura, T., Imachi, H., Kobayashi, T., Saheki, T., Sato, S., Saheki, N., Jiang, W., & Murao, K. (2023). A Pilot Study on the Efficacy of a Diabetic Diet Containing the Rare Sugar D-Allulose in Patients with Type 2 Diabetes Mellitus: A Prospective, Randomized, Single-Blind, Crossover Study. Nutrients, 15(12), 2802.

Iwasaki, Y., Sendo, M., Dezaki, K., Hira, T., Sato, T., Nakata, M., Goswami, C., Aoki, R., Arai, T., Kumari, P., Hayakawa, M., Masuda, C., Okada, T., Hara, H., Drucker, D. J., Yamada, Y., Tokuda, M., & Yada, T. (2018). GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose. Nature Communications, 9, 113.

Rakhat, Y., Kaneko, K., Wang, L., Han, W., Seino, Y., Yabe, D., & Yada, T. (2022). d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice. Nutrients, 14(15), 3117.

Yermek, R., Wang, L., Kaneko, K., Han, W., Seino, Y., Yabe, D., & Yada, T. (2022). D-Allulose cooperates with glucagon-like peptide-1 and activates proopiomelanocortin neurons in the arcuate nucleus and central injection inhibits feeding in mice. Biochemical and Biophysical Research Communications, 613, 159-165.

Han, Y., Kwon, E.-Y., Yu, M. K., Lee, S. J., Kim, H.-J., Kim, S.-B., Kim, Y. H., & Choi, M.-S. (2018). A Preliminary Study for Evaluating the Dose-Dependent Effect of d-Allulose for Fat Mass Reduction in Adult Humans: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 10(2), 160.

Hossain, A., Yamaguchi, F., Matsuo, T., Tsukamoto, I., Toyoda, Y., Ogawa, M., Nagata, Y., & Tokuda, M. (2015). Rare sugar d-allulose: Potential role and therapeutic monitoring in maintaining obesity and type 2 diabetes mellitus. Pharmacology & Therapeutics, 155, 49-59.

Ochiai, M., Onishi, K., Yamada, T., Iida, T., & Matsuo, T. (2014). d-Psicose increases energy expenditure and decreases body fat accumulation in rats fed a high-sucrose diet. International Journal of Food Sciences and Nutrition, 65(2), 245-250.

Perlmutter, D. (July 19, 2023). Yes, I'm excited about allulose. Dr. Perlmutter.